Article
Clonal divergence and genetic heterogeneity in clear cell renal cell carcinomas with sarcomatoid transformation
26 Jul 2005
Abstract excerpt
BACKGROUND: Approximately 5% of clear cell renal cell carcinomas contain components with sarcomatoid differentiation. It has been suggested that the sarcomatoid elements arise from the clear cell tumors as a consequence of clonal expansions of neoplastic cells with progressively more genetic alterations. Analysis of the pattern of allelic loss and X-chromosome inactivation in both the clear cell and sarcomatoid...
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