Dual effect of a single nucleotide polymorphism in the first intron of the porcine secreted phosphoprotein 1 gene: allele-specific binding of C/EBP beta and activation of aberrant splicing.

doi:10.1186/1471-2199-10-96

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Article

Dual effect of a single nucleotide polymorphism in the first intron of the porcine secreted phosphoprotein 1 gene: allele-specific binding of C/EBP beta and activation of aberrant splicing.

BMC molecular biology - 21 Oct 2009

Muráni Eduard, Ponsuksili Siriluck, Seyfert Hans-Martin, Shi Xuanming, Wimmers Klaus

Abstract excerpt

BACKGROUND: Secreted phosphoprotein 1 (SPP1 or Osteopontin, OPN) is a multifunctional matricellular glycoprotein involved in development and regeneration of skeletal muscle. Previously, we have demonstrated that porcine SPP1 shows breed-related differential mRNA expression during myogenesis. With the aim to identify putative contributing cis-regulatory DNA variation we resequenced the 5' upstream region of the...

Topics

5' Untranslated Regions
Alleles
Alternative Splicing
Animals
Base Sequence
Binding Sites
CCAAT-Enhancer-Binding Protein-beta
Cattle
Computational Biology
Conserved Sequence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Electrophoretic Mobility Shift Assay

Evolution, Molecular

Fetus

Gene Expression Profiling

Genotype

Introns

Molecular Sequence Data

Muscles

Source

Open in PubMed Open full text

Identifiers

PMID: 19845957
DOI: 10.1186/1471-2199-10-96
PMCID: PMC2773772

Genes

SPP1
EBP

Provenance

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