Article
A codon change in beta-tubulin which drastically affects microtubule structure in Drosophila melanogaster fails to produce a significant phenotype in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Sept 1991
Praitis V, Katz W S, Solomon F
Abstract excerpt
The relative uniformity of microtubule ultrastructure in almost all eukaryotic cells is thought to be a consequence of the conserved elements of tubulin sequence. In support of this idea, a mutation in a beta-tubulin gene of Drosophila melanogaster, occurring at a highly conserved position, produces U-shaped microtubules, suggesting a defect in either nucleation or packing during assembly (M. T. Fuller, J. H....
Topics
- Animals
- Base Sequence
- Benomyl
- Blotting, Southern
- Blotting, Western
- Cloning, Molecular
- Codon
- DNA, Fungal
- Drosophila melanogaster
- Drug Resistance, Microbial
- Genes, Fungal