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Article

Multiple distinct clones may co-exist in different lineages in myelodysplastic syndromes.

Leukemia research - 1 Jun 2009

Huang Wan-Ting, Yang Xiaorong, Zhou Xiaobo, Monzon Federico A, Wen Jianguo, Hagenkord Jill M, Wu Ling-Yun, Keever-Taylor Carolyn, Novoa-Takara Louis, Wong Stephen T C, Young Kenneth, Chang Chung-Che

Abstract excerpt

Using single nucleotide polymorphism (SNP) microarray with unfractionized bone marrow specimens, recent studies have demonstrated that multiple cytogenetically cryptic genomic aberrations, uniparental disomy (UPD) and/or copy number (CN) aberration, are present in patients with myelodysplastic syndromes (MDS). We hypothesize that various hematopoietic lineages in MDS may carry different cytogenetically cryptic...

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PMID: 19084271
DOI: 10.1016/j.leukres.2008.10.008

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