Variability of Outer Membrane Protein P1 and Its Evaluation as a Vaccine Candidate against Experimental Otitis Media due to NontypeableHaemophilus influenzae: an Unambiguous, Multifaceted Approach

doi:10.1128/iai.68.8.4505-4517.2000

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Article

Variability of Outer Membrane Protein P1 and Its Evaluation as a Vaccine Candidate against Experimental Otitis Media due to NontypeableHaemophilus influenzae: an Unambiguous, Multifaceted Approach

1 Aug 2000

Abstract excerpt

Candidate vaccine antigens for preventing otitis media caused by nontypeable Haemophilus influenzae (NTHI) should possess one or more conserved epitopes. We sought to evaluate the candidacy of P1, a surface-expressed outer membrane protein knowing that this antigen is subject to diversifying selection. Therefore, we selected NTHI strains from among >500 phylogenically variant isolates representative of the...

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PMID: 10899849
DOI: 10.1128/iai.68.8.4505-4517.2000

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