Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Opposite effects of Ras or PKC activation on the expression of the SPRR2A keratinocyte terminal differentiation marker.

Experimental cell research - 1 Aug 1999

Sark M W, Borgstein A M, Medema J P, van de Putte P, Backendorf C

Abstract excerpt

Epidermal growth factor (EGF) enhances the expression of the keratinocyte terminal differentiation marker SPRR2A, when added to monolayers of basal keratinocytes, induced to stratify by increasing the extracellular calcium concentration. A similar stimulation is found during suspension-induced differentiation in methylcellulose. This effect, which is observed after several hours of EGF addition, is restricted to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epidermal Growth Factor
Share to Genes, fos

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Keratinocytes

Share to Maleimides

Share to Oncogene Protein p21(ras)

Share to Protein Kinase C

Share to Proto-Oncogene Proteins c-jun

Share to Tetradecanoylphorbol Acetate

Source

Identifiers

PMID: 10413601
DOI: 10.1006/excr.1999.4532

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Opposite effects of Ras or PKC activation on the expression of the SPRR2A keratinocyte terminal differentiation marker.PMID 10413601Read ↗

Phorbol ester-induced expression of airway squamous cell differentiation marker, SPRR1B, is regulated by protein kinase Cdelta /Ras/MEKK1/MKK1-dependent/AP-1 signal transduction pathway.Semantic proximity Read ↗

Signal Transduction Pathways Controlling the Switch Between Keratinocyte Growth and DifferentiationSemantic proximity Read ↗

Regulation of keratinocyte proliferation and differentiation by all-trans-retinoic acid, 9-cis-retinoic acid and 1,25-dihydroxy vitamin D3.Semantic proximity Read ↗

The receptor tyrosine kinase FGFR2b/KGFR controls early differentiation of human keratinocytes.Semantic proximity Read ↗

Ras-induced spreading and wound closure in human epidermal keratinocytes.Semantic proximity Read ↗

Direct binding of RalA to PKCη and its crucial role in morphological change during keratinocyte differentiation.Semantic proximity Read ↗

Alterations in epidermal biochemistry as a consequence of stage-specific genetic changes in skin carcinogenesis.Semantic proximity Read ↗

TGF-beta and retinoic acid: regulators of growth and modifiers of differentiation in human epidermal cells.Semantic proximity Read ↗

Cyclic AMP differentially regulates cell proliferation of normal human keratinocytes through ERK activation depending on the expression pattern of B-RafSemantic proximity Read ↗

Analysis of v-Ha-ras and v-fos oncogene transduction into a mouse epidermal cell line with "initiated" phenotype in culture but normal skin phenotype in vivo.Semantic proximity Read ↗

p63 and p73 Transactivate Differentiation Gene Promoters in Human KeratinocytesSemantic proximity Read ↗

Caspase activation in the terminal differentiation of human epidermal keratinocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.