Article
The Asp298 allele of endothelial nitric oxide synthase is a risk factor for myocardial infarction among patients with type 2 diabetes mellitus.
BMC cardiovascular disorders - 10 Dec 2008
Odeberg Jacob, Larsson Charlotte A, Råstam Lennart, Lindblad Ulf
Abstract excerpt
BACKGROUND: Endothelial dysfunction plays a central role in atherosclerotic progression and cardiovascular complications of type 2 diabetes mellitus (T2DM). Given the role of nitric oxide in the vascular system, we aimed to test hypotheses of synergy between the common endothelial nitric oxide synthase (eNOS) Asp298 allele and T2DM in predisposing to acute myocardial infarction (AMI). METHODS: In a...
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