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Article

Transient Gene Expression by Nonintegrating Lentiviral Vectors

24 Mar 2006

Abstract excerpt

Nonintegrating lentiviral (NIL) vectors were produced from HIV-1-based lentiviral vectors by introducing combinations of mutations made to disable the integrase protein itself and to alter the integrase recognition sequences (att) in the viral LTR. NIL vectors with these novel combinations of mutations were used to transduce the human T lymphoid cell line Jurkat and primary human CD34(+) hematopoietic progenitor...

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Identifiers

PMID: 16556511
DOI: 10.1016/j.ymthe.2006.01.008

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