Article
The transition of closely opposed lesions to double-strand breaks during long-patch base excision repair is prevented by the coordinated action of DNA polymerase delta and Rad27/Fen1.
Molecular and cellular biology - 1 Mar 2009
Ma Wenjian, Panduri Vijayalakshmi, Sterling Joan F, Van Houten Bennett, Gordenin Dmitry A, Resnick Michael A
Abstract excerpt
DNA double-strand breaks can result from closely opposed breaks induced directly in complementary strands. Alternatively, double-strand breaks could be generated during repair of clustered damage, where the repair of closely opposed lesions has to be well coordinated. Using single and multiple mutants of Saccharomyces cerevisiae (budding yeast) that impede the interaction of DNA polymerase delta and the 5'-flap...
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