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Article

Differential association of cytochrome P450 3A4 genotypes with onsets of breast tumors in African American versus Caucasian patients.

Journal of investigative medicine : the official publication of the American Federation for Clinical Research - 1 Oct 2011

McDaniel D Olga, Thurber Tonya, Lewis-Traylor Angela, Berry Crystal, Barber William Henry, Zhou Xinchun, Bigler Steven, Vance Ralph

Abstract excerpt

INTRODUCTION: Malignant breast tumors are often hormone-dependent, and to this end, both estrogen and progesterone receptors are good prognostic markers for evaluation of the outcomes after therapy. In addition, HER-2/neu, whose expression is increasingly being associated with poor prognosis of breast cancer, has predictive potential after immunotherapy. Cytochrome P450 3A4 is highly involved in the metabolism of...

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PMID: 21750466
DOI: 10.2310/JIM.0b013e3182277e3b

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