Article
Stromal cell-derived factor-1 (SDF-1) alleles and susceptibility to breast carcinoma.
Cancer letters - 28 Jul 2005
Razmkhah Mahboobeh, Talei Abdul-Rasoul, Doroudchi Mehrnoosh, Khalili-Azad Tahereh, Ghaderi Abbas
Abstract excerpt
Stromal cell-Derived Factor-1 (SDF-1, CXCL12) is one the ELR- CXC angiogenic chemokines. It contributes to hematopoiesis and lymphocyte trafficking. SDF-1 and its exclusive receptor, CXCR4, are reported to play important roles in tumor growth, angiogenesis and metastasis of different types of tumors such as breast, lung, prostate and pancreatic cancers. SDF-1 gene polymorphism, known as SDF1-3'A, has been...
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