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Article

Mesenchymal stem cell-mediated ectopic hematopoiesis alleviates aging-related phenotype in immunocompromised mice.

Blood - 12 Mar 2009

Yamaza Takayoshi, Miura Yasuo, Akiyama Kentaro, Bi Yanming, Sonoyama Wataru, Gronthos Stan, Chen Wanjun, Le Anh, Shi Songtao

Abstract excerpt

Subcutaneous transplants of bone marrow mesenchymal stem cells (BMMSCs) are capable of generating ectopic bone and organizing functional hematopoietic marrow elements in animal models. Here we report that immunocompromised mice received subcutaneous BMMSC transplants using hydroxyapatite tricalcium phosphate as a carrier suppressed age-related degeneration in multiple organs and benefited an increase in life span...

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Identifiers

PMID: 19074727
DOI: 10.1182/blood-2008-10-182246
PMCID: PMC2656279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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