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Article

Inhibition of TGFβ improves hematopoietic stem cell niche and ameliorates cancer-related anemia

18 Jan 2021

Abstract excerpt

BACKGROUND: Cancer cachexia is a wasting syndrome that is quite common in terminal-stage cancer patients. Cancer-related anemia is one of the main features of cancer cachexia and mostly results in a poor prognosis. The disadvantages of the current therapies are obvious, but few new treatments have been developed because the pathological mechanism remains unclear. METHODS: C57BL/6 mice were subcutaneously injected...

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PMID: 33461597
DOI: 10.1186/s13287-020-02120-9

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