Article
[Paroxysmal nocturnal hemoglobinuria (PNH)].
Nihon rinsho. Japanese journal of clinical medicine - 1 Mar 2008
Nishimura Jun-ichi, Kanakura Yuzuru
Abstract excerpt
Paroxysmal nocturnal hemoglobinuria is an acquired hematopoietic stem cell disorder. The most common clinical manifestations of PNH include intravascular hemolysis, venous thrombosis, and bone marrow failure. Hematopoietic stems cells with mutant PIG-A are present in normal marrow, but they are not noticed because they have no advantage under normal circumstances. In the setting of immune-mediated bone marrow...
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