Article
Splice variants of neuronal nitric oxide synthase are present in the rat kidney.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 1 May 2009
Smith Cheryl, Merchant Michael, Fekete Andrea, Nyugen Ha-Long, Oh Paul, Tain You-Lin, Klein Jon B, Baylis Chris
Abstract excerpt
BACKGROUND: Decreased renal cortical neuronal NO synthase (nNOS) abundance/activity correlates with progression of chronic kidney disease (CKD) in a number of animal models. METHODS: Western blotting with both N-terminal and C-terminal antibodies, immunoprecipitation, proteomics, RT-PCR and in situ hybridization were used to identify nNOS splice variants in the rat kidney. RESULTS: We have identified two nNOS...
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