Article
Do BRCA1 modifiers also affect the risk of breast cancer in non-carriers?
European journal of cancer (Oxford, England : 1990) - 1 Mar 2009
Jakubowska Anna, Jaworska Katarzyna, Cybulski Cezary, Janicka Anna, Szymańska-Pasternak Jolanta, Lener Marcin, Narod Steven A, Lubiński Jan
Abstract excerpt
We studied whether or not single nucleotide polymorphisms (SNPs), which have been shown to modify the risk of breast cancer in women with a BRCA1 mutation, are associated with cancer risk in unselected (non-hereditary) breast cancer patients. We genotyped seven SNPs in six distinct genes (PHB, RAD51, ITGB3, TGFB1, VEGF, MTHFR) in 1100 unselected Polish breast cancer patients and 1100 controls. The frequencies of...
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