Article
Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study.
British journal of cancer - 5 Jun 2012
Jakubowska A, Rozkrut D, Antoniou A, Hamann U, Scott R J, McGuffog L, Healy S, Sinilnikova O M, Rennert G, Lejbkowicz F, Flugelman A, Andrulis I L, Glendon G, Ozcelik H, Thomassen M, Paligo M, Aretini P, Kantala J, Aroer B, von Wachenfeldt A, Liljegren A, Loman N, Herbst K, Kristoffersson U, Rosenquist R, Karlsson P, Stenmark-Askmalm M, Melin B, Nathanson K L, Domchek S M, Byrski T, Huzarski T, Gronwald J, Menkiszak J, Cybulski C, Serrano P, Osorio A, Cajal T R, Tsitlaidou M, Benítez J, Gilbert M, Rookus M, Aalfs C M, Kluijt I, Boessenkool-Pape J L, Meijers-Heijboer H E J, Oosterwijk J C, van Asperen C J, Blok M J, Nelen M R, van den Ouweland A M W, Seynaeve C, van der Luijt R B, Devilee P, Easton D F, Peock S, Frost D, Platte R, Ellis S D, Fineberg E, Evans D G, Lalloo F, Eeles R, Jacobs C, Adlard J, Davidson R, Eccles D, Cole T, Cook J, Godwin A, Bove B, Stoppa-Lyonnet D, Caux-Moncoutier V, Belotti M, Tirapo C, Mazoyer S, Barjhoux L, Boutry-Kryza N, Pujol P, Coupier I, Peyrat J-P, Vennin P, Muller D, Fricker J-P, Venat-Bouvet L, Johannsson O Th, Isaacs C, Schmutzler R, Wappenschmidt B, Meindl A, Arnold N, Varon-Mateeva R, Niederacher D, Sutter C, Deissler H, Preisler-Adams S, Simard J, Soucy P, Durocher F, Chenevix-Trench G, Beesley J, Chen X, Rebbeck T, Couch F, Wang X, Lindor N, Fredericksen Z, Pankratz V S, Peterlongo P, Bonanni B, Fortuzzi S, Peissel B, Szabo C, Mai P L, Loud J T, Lubinski J
Abstract excerpt
BACKGROUND: The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), both of which are important either directly or indirectly in maintaining genomic integrity. METHODS: To evaluate the potential role of genetic variants...
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