Article
A neuropeptide-mediated stretch response links muscle contraction to changes in neurotransmitter release.
Neuron - 14 Jul 2011
Hu Zhitao, Pym Edward C G, Babu Kavita, Vashlishan Murray Amy B, Kaplan Joshua M
Abstract excerpt
Although Caenorhabditis elegans has been utilized extensively to study synapse formation and function, relatively little is known about synaptic plasticity in C. elegans. We show that a brief treatment with the cholinesterase inhibitor aldicarb induces a form of presynaptic potentiation whereby ACh release at neuromuscular junctions (NMJs) is doubled. Aldicarb-induced potentiation was eliminated by mutations that...
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