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Article

MTHFR 677C-->T and 1298A-->C polymorphisms in children with Down syndrome and acute myeloid leukemia in Brazil.

Pediatric hematology and oncology - 1 Dec 2008

Amorim Marcia R, Zanrosso Crisiane Wais, Magalhães Isis Q, Pereira Simone C, Figueiredo Alexandre, Emerenciano Mariana, Pinheiro Vitoria Regia, d'Andréa Maria Lydia, Orioli Ieda M, Koifman Sergio, Pombo-de-Oliveira Maria S

Abstract excerpt

Down syndrome (DS) is an important risk factor associated with acute leukemia (AL). The presence of polymorphisms that reduce 5,10-methylenetetrahydrofolate reductase (MTHFR) activity has been linked to the multifactorial leukemogenic process. The authors have conducted a study to test whether 67...

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Source

Identifiers

PMID: 19065440
DOI: 10.1080/08880010802435104

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19065440-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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