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Article

MTHFR 677C>T and 1298A>C Variants in Mothers of Infants with Down Syndrome from Western Mexico.

Genetic testing and molecular biomarkers - 1 Jun 2024

Romero-Bolaño Yaneris Maibeth, Bobadilla-Morales Lucina, Corona-Rivera Alfredo, Cuero-Quezada Idalid, Santana-Hernández Jennifer, Peña-Padilla Christian, Brukman-Jiménez Alejandro, Orozco-Vela Mireya, Navia-Espinoza Natalia, Corona-Rivera Jorge Román

Abstract excerpt

Background: Several studies in mothers of infants with Down syndrome (DS) (MoIDS) have suggested that the 677C>T and 1298A>C variants of the 5,10-methylentetrahydrofolate reductase (MTHFR) gene can increase the risk of having a child with DS. Aim: This study aimed to evaluate the MTHFR 677C>T and 1298A>C variants as potential maternal risk factors for DS. Materials and Methods: Using TaqMan allelic discrimination...

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Identifiers

PMID: 38717090
DOI: 10.1089/gtmb.2023.0690

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