Article
Distinct thresholds govern Myc's biological output in vivo.
Cancer cell - 9 Dec 2008
Murphy Daniel J, Junttila Melissa R, Pouyet Laurent, Karnezis Anthony, Shchors Ksenya, Bui Duyen A, Brown-Swigart Lamorna, Johnson Leisa, Evan Gerard I
Abstract excerpt
Deregulated Myc triggers a variety of intrinsic tumor suppressor programs that serve to restrain Myc's oncogenic potential. Since Myc activity is also required for normal cell proliferation, activation of intrinsic tumor suppression must be triggered only when Myc signaling is oncogenic. However, how cells discriminate between normal and oncogenic Myc is unknown. Here we show that distinct threshold levels of Myc...
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