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Article

Impact of MYC on malignant behavior

24 Nov 2014

Abstract excerpt

MYC, a member of the helix-loop-helix leucine zipper family of nuclear transcription factors, is a potent proto-oncogene primarily identified as the target of the t(8;14)(q24;q32) chromosome translocation in Burkitt lymphoma. Activation of the MYC gene in normal cells both results in enhanced cellular proliferation and up-regulation of pro-apoptotic pathways, reflecting the tight regulation of the molecule in the...

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PMID: 25696841
DOI: 10.1182/asheducation-2014.1.100

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