Article
An improved method for the detection of differential survival between normal and xeroderma pigmentosum lymphoblastoid cell lines in culture with 4-nitroquinoline-1-oxide.
Mutation research - 1 Jul 1991
Kiyohara C, Hirohata T, Kuratsune M, Nagayama J
Abstract excerpt
The effects of the UV-mimetic chemical 4-nitroquinoline-1-oxide (4-NQO) upon cell lines heterozygous or homozygous for the recessive mutant xeroderma pigmentosum (XP) were investigated. Human lymphoblastoid cell lines, which were established from 4 XP homozygote patients (XPL15, XPL17, XPL19 and XPL20). 2 XP heterozygote individuals (XPPL17 and XPML17) and 58 normal individuals, were cultured in the presence of...
Topics
- 4-Nitroquinoline-1-oxide
- Cell Division
- Cell Line
- Cell Survival
- Heterozygote
- Homozygote
- Humans
- Leukemia, Lymphoid
- Mutation
- Xeroderma Pigmentosum