Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B.

doi:10.3324/haematol.13378

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Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B.

Haematologica - 1 Jan 2009

Schlenk Richard F, Döhner Konstanze, Kneba Michael, Götze Katharina, Hartmann Frank, Del Valle Francesco, Kirchen Heinz, Koller Elisabeth, Fischer Jörg T, Bullinger Lars, Habdank Marianne, Späth Daniela, Groner Silja, Krebs Bernhard, Kayser Sabine, Corbacioglu Andrea, Anhalt Andreas, Benner Axel, Fröhling Stefan, Döhner Hartmut

Abstract excerpt

BACKGROUND: In a previous randomized trial, AML HD98B, we showed that administration of all-trans retinoic acid in addition to intensive chemotherapy improved the outcome of older patients with acute myeloid leukemia. The objectives of this study were to evaluate the prognostic impact of gene mutations and to identify predictive genetic factors for the all-trans retinoic acid treatment effect. DESIGN AND METHODS:...

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Identifiers

PMID: 19059939
DOI: 10.3324/haematol.13378
PMCID: PMC2625424

Genes

NPM1
FLT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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