Age-dependent frequencies of NPM1 mutations and FLT3-ITD in patients with normal karyotype AML (NK-AML).

doi:10.1007/s00277-011-1280-6

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Age-dependent frequencies of NPM1 mutations and FLT3-ITD in patients with normal karyotype AML (NK-AML).

Annals of hematology - 1 Jan 2012

Schneider Friederike, Hoster Eva, Schneider Stephanie, Dufour Annika, Benthaus Tobias, Kakadia Purvi M, Bohlander Stefan K, Braess Jan, Heinecke Achim, Sauerland Maria C, Berdel Wolfgang E, Buechner Thomas, Woermann Bernhard J, Feuring-Buske Michaela, Buske Christian, Creutzig Ursula, Thiede Christian, Zwaan Michel C, van den Heuvel-Eibrink Marry M, Reinhardt Dirk, Hiddemann Wolfgang, Spiekermann Karsten

Abstract excerpt

Prognosis of AML in elderly patients is poor due to adverse patient characteristics and comorbidities. In addition, disease-associated parameters reveal differences between older and younger patients with AML. Survival in normal karyotype AML (NK-AML) is influenced by different clinical and molecular markers. The aim of this work was to investigate the frequencies of molecular markers in patients with NK-AML with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fms-Like Tyrosine Kinase 3

Share to Karyotype

Share to Leukemia, Myeloid, Acute

Share to Nuclear Proteins

Share to Nucleophosmin

Share to Survival Rate

Share to Tandem Repeat Sequences

Source

Open in PubMed

Identifiers

PMID: 21744003
DOI: 10.1007/s00277-011-1280-6

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age-dependent frequencies of NPM1 mutations and FLT3-ITD in patients with normal karyotype AML (NK-AML).PMID 21744003Read ↗

Karyotype plus NPM1 mutation status defines a group of elderly patients with AML (≥60 years) who benefit from intensive post-induction consolidation therapy.Semantic proximity Read ↗

Prognostic factors in normal karyotype acute myeloid leukemia in the absence of the FLT3-ITD mutation.Semantic proximity Read ↗

Mutational spectrum of de novo NPM1-mutated acute myeloid leukemia patients older than 75 years.Semantic proximity Read ↗

Associations between age, cytogenetics, FLT3-ITD, and marrow leukemia cells identified by flow cytometry.Semantic proximity Read ↗

The effect of FLT3-ITD and NPM1 mutation on survival in intensively treated elderly patients with cytogenetically normal acute myeloid leukemia - Response to Rashidi et al.Semantic proximity Read ↗

Favorable prognostic impact of NPM1 mutations in older patients with cytogenetically normal de novo acute myeloid leukemia and associated gene- and microRNA-expression signatures: a Cancer and Leukemia Group B study.Semantic proximity Read ↗

Incidence and significance of FLT3-ITD and NPM1 mutations in patients with normal karyotype acute myeloid leukaemia.Semantic proximity Read ↗

The prognostic impact of FLT3-ITD and NPM1 mutation in adult AML is age-dependent in the population-based setting.Semantic proximity Read ↗

Prognostic significance of NPM1 mutations in the absence of FLT3-internal tandem duplication in older patients with acute myeloid leukemia: a SWOG and UK National Cancer Research Institute/Medical Research Council report.Semantic proximity Read ↗

Prognostic value of immunophenotyping and gene mutations in elderly patients with acute myeloid leukemia with normal karyotype.Semantic proximity Read ↗

The effect of FLT3-ITD and NPM1 mutation on survival in intensively treated elderly patients with cytogenetically normal acute myeloid leukemia.Semantic proximity Read ↗

Age-dependent clinical, molecular, and prognostic differences in patients with AML: a retrospective study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.