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Article

Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia.

The New England journal of medicine - 1 May 2008

Schlenk Richard F, Döhner Konstanze, Krauter Jürgen, Fröhling Stefan, Corbacioglu Andrea, Bullinger Lars, Habdank Marianne, Späth Daniela, Morgan Michael, Benner Axel, Schlegelberger Brigitte, Heil Gerhard, Ganser Arnold, Döhner Hartmut

Abstract excerpt

BACKGROUND: Mutations occur in several genes in cytogenetically normal acute myeloid leukemia (AML) cells: the nucleophosmin gene (NPM1), the fms-related tyrosine kinase 3 gene (FLT3), the CCAAT/enhancer binding protein alpha gene (CEPBA), the myeloid-lymphoid or mixed-lineage leukemia gene (MLL), and the neuroblastoma RAS viral oncogene homolog (NRAS). We evaluated the associations of these mutations with...

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Source

Identifiers

PMID: 18450602
DOI: 10.1056/NEJMoa074306

Genes

FLT3
NPM1
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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