Article
Role of the hexapeptide disulfide loop present in the gamma-carboxyglutamic acid domain of human protein C in its activation properties and in the in vitro anticoagulant activity of activated protein C.
Biochemistry - 9 Jul 1991
Zhang L, Castellino F J
Abstract excerpt
In order to examine whether the structural integrity of the hexapeptide disulfide loop (residues 17-22), present in the gamma-carboxyglutamic acid (gamma) domain of human protein C (PC), and common to all vitamin K dependent coagulation proteins, is necessary for its anticoagulant properties, we...
Topics
- 1-Carboxyglutamic Acid
- Anticoagulants
- Base Sequence
- Blotting, Western
- Calcium
- Cells, Cultured
- Chromatography, Liquid
- DNA
- Disulfides
- Electrophoresis, Polyacrylamide Gel
- Enzyme Activation
- Factor VIII
- Humans
- Kidney
- Molecular Sequence Data
- Mutation
- Oligopeptides
- Protein C