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Article

Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo

1 Apr 1992

Abstract excerpt

Strains of human immunodeficiency virus type 1 differ in their abilities to infect and replicate in primary human macrophages. Chimeric clones were constructed from a provirus unable to infect macrophages (NLHX) and envelope sequences (V3 loop) of viruses derived without cultivation from brain (YU2 and w1-1c1) or spleen (w2-1b4) tissues. The substituted V3 loop sequences in each case were sufficient to confer...

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Identifiers

PMID: 1548783
DOI: 10.1128/jvi.66.4.2577-2582.1992

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