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Article

Growth defects in mouse telomerase RNA-deficient cells expressing a template-mutated mouse telomerase RNA.

Cancer letters - 18 Mar 2009

Marie-Egyptienne Delphine T, Brault Marie Eve, Nimmo Graeme A M, Londoño-Vallejo J Arturo, Autexier Chantal

Abstract excerpt

Cellular viability requires telomere maintenance, which, in mammals, is mainly mediated by the reverse transcriptase telomerase. Telomerase core components are a catalytic subunit TERT and an RNA subunit TR (hTR in humans, mTR in mouse) that carries the template to generate telomeres de novo. Telomere dysfunction can lead to senescence or apoptosis and impairs the continued growth of immortal cancerous cell...

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Identifiers

PMID: 19056167
DOI: 10.1016/j.canlet.2008.10.027

Genes

TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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