Article
Mutational analysis defines a minimum level of telomerase activity required for tumourigenic growth of human cells.
Oncogene - 10 Oct 2002
Hamad Nesrin M, Banik Soma S R, Counter Christopher M
Abstract excerpt
A hallmark of cancer cells is the ability to proliferate indefinitely. This acquisition of an immortal lifespan usually requires the activation of telomerase, the enzyme that elongates telomeres. Human telomerase is minimally composed of the reverse transcriptase subunit hTERT, and the RNA subunit hTR. While hTR is ubiquitously expressed in human cells, the hTERT subunit is generally transcriptionally repressed...
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