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Article

Telomerase inhibition in a mouse cell line with long telomeres leads to rapid telomerase reactivation.

Experimental cell research - 1 Feb 2008

Marie-Egyptienne Delphine T, Brault Marie Eve, Zhu Shusen, Autexier Chantal

Abstract excerpt

The indefinite growth of cancer cells requires telomere maintenance, which, in the majority of mammalian cancers is mediated via the enzyme telomerase. The core components of telomerase are a catalytic reverse transcriptase (hTERT in human, mTERT in mouse) and an RNA (TR) that contains the template for the replenishment of telomeres. Fundamental differences in human and mouse telomerase and telomere biology...

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Identifiers

PMID: 18067891
DOI: 10.1016/j.yexcr.2007.10.020

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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