A reduced peripheral blood CD4(+) lymphocyte proportion is a consistent ageing phenotype.

doi:10.1016/s0047-6374(01)00347-5

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Article

A reduced peripheral blood CD4(+) lymphocyte proportion is a consistent ageing phenotype.

Mechanisms of ageing and development - 1 Jan 2002

Chen Jichun, Flurkey Kevin, Harrison David E

Abstract excerpt

Peripheral blood leukocyte composition was measured in young, middle-aged and old C57BL/6J (B6) and BALB/cByJ (BALB) mice by flow cytometry to test the hypothesis that ageing is associated with declines in the proportions of peripheral blood T lymphocytes. In both B6 and BALB mice, increasing age is associated with a significant and continuous decline in the proportions of CD4(+) lymphocytes, a moderate decline...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11718808
DOI: 10.1016/s0047-6374(01)00347-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.