Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abnormal cytoplasmic dyslocalisation and/or reduction of nucleophosmin protein level rarely occurs in myelodysplastic syndromes.

Leukemia & lymphoma - 1 Dec 2008

Ishikawa Yuichi, Xu Jinglan, Sakashita Gyosuke, Urano Takeshi, Suzuki Tatsuya, Tomita Akihiro, Kiyoi Hitoshi, Nakamura Shigeo, Naoe Tomoki

Abstract excerpt

The Nucleophosmin1 (NPM1) gene located in chromosome 5q35 is affected by chromosomal translocation, mutation and deletion in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). NPM1 haploinsufficiency reportedly causes MDS-like disorders in knockout mice. Here, we studied mRNA and protein expression in bone marrow (BM) samples from 36 patients with MDS. The NPM1 expression levels of mRNA and protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow
Share to Chromosome Aberrations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoplasm

Share to Disease Progression

Share to Myelodysplastic Syndromes

Share to Nuclear Proteins

Share to Nucleophosmin

Share to RNA, Messenger

Source

Identifiers

PMID: 19052985
DOI: 10.1080/10428190802541815

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormal cytoplasmic dyslocalisation and/or reduction of nucleophosmin protein level rarely occurs in myelodysplastic syndromes.PMID 19052985Read ↗

Nucleophosmin: A versatile molecule associated with hematological malignanciesSemantic proximity Read ↗

Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse.Semantic proximity Read ↗

Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish.Semantic proximity Read ↗

Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications.Semantic proximity Read ↗

Any role for the nucleophosmin (NPM1) gene in myelodysplastic syndromes and acute myeloid leukemia with chromosome 5 abnormalities?Semantic proximity Read ↗

Lack of nucleophosmin mutation in patients with myelodysplastic syndrome and acute myeloid leukemia with chromosome 5 abnormalities.Semantic proximity Read ↗

Acute myeloid leukemia with mutated nucleophosmin (NPM1): molecular, pathological, and clinical features.Semantic proximity Read ↗

Role of nucleophosmin in acute myeloid leukemia.Semantic proximity Read ↗

Nucleophosmin1 (NPM1) abnormality in hematologic malignancies, and therapeutic targeting of mutant NPM1 in acute myeloid leukemiaSemantic proximity Read ↗

A knock-in Npm1 mutation in mice results in myeloproliferation and implies a perturbation in hematopoietic microenvironment.Semantic proximity Read ↗

[Nucleophosmin mutations in hematological malignancies - review].Semantic proximity Read ↗

Cytoplasmic mutated nucleophosmin (NPM) defines the molecular status of a significant fraction of myeloid sarcomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.