Article
Ktu/PF13 is required for cytoplasmic pre-assembly of axonemal dyneins.
Nature - 4 Dec 2008
Omran Heymut, Kobayashi Daisuke, Olbrich Heike, Tsukahara Tatsuya, Loges Niki T, Hagiwara Haruo, Zhang Qi, Leblond Gerard, O'Toole Eileen, Hara Chikako, Mizuno Hideaki, Kawano Hiroyuki, Fliegauf Manfred, Yagi Toshiki, Koshida Sumito, Miyawaki Atsushi, Zentgraf Hanswalter, Seithe Horst, Reinhardt Richard, Watanabe Yoshinori, Kamiya Ritsu, Mitchell David R, Takeda Hiroyuki
Abstract excerpt
Cilia and flagella are highly conserved organelles that have diverse roles in cell motility and sensing extracellular signals. Motility defects in cilia and flagella often result in primary ciliary dyskinesia. However, the mechanisms underlying cilia formation and function, and in particular the cytoplasmic assembly of dyneins that power ciliary motility, are only poorly understood. Here we report a new gene,...
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