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Article

A critical evaluation of genomic control methods for genetic association studies.

Genetic epidemiology - 1 May 2009

Dadd Tony, Weale Michael E, Lewis Cathryn M

Abstract excerpt

Population stratification is an important potential confounder of genetic case-control association studies. For replication studies, limited availability of samples may lead to imbalanced sampling from heterogeneous populations. Genomic control (GC) can be used to correct chi(2) test statistics which are presumed to be inflated by a factor lambda; this may be estimated by a summary chi(2) value (lambda(median) or...

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PMID: 19051284
DOI: 10.1002/gepi.20379

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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