Delta-centralization fails to control for population stratification in genetic association studies.

Abstract excerpt

OBJECTIVE: To investigate the validity of simulations and assumptions used to underpin the delta-centralization (DC) method for correcting for population stratification in genetic association studies; to assess the effectiveness of DC compared to genomic control (GC) under valid simulation conditions; and to highlight other studies employing similarly flawed simulations. METHODS: DC and GC use data from unlinked...

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