Article
Antiretroviral combinations implicated in emergence of the L74I and L74V resistance mutations in HIV-1-infected patients.
AIDS (London, England) - 2 Jan 2009
Wirden Marc, Lambert-Niclot Sidonie, Marcelin Anne-Genevieve, Schneider Luminita, Ait-Mohand Hocine, Brunet Christel, Angleraud Francis, Amard Sylvain, Katlama Christine, Calvez Vincent
Abstract excerpt
BACKGROUND: Very little is known about the alternative L74I mutation. This lack of knowledge has led to contradictory and confusing attitudes to L74I; although this mutation is not listed by the International AIDS Society - USA, it is increasingly included in several resistance algorithms. OBJECTIVE: To compare and clarify the role of each antiretroviral compound and the resistance background in the emergence of...
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