Article
HIV-1 disease-influencing effects associated with ZNRD1, HCP5 and HLA-C alleles are attributable mainly to either HLA-A10 or HLA-B*57 alleles.
PloS one - 1 Jan 2008
Catano Gabriel, Kulkarni Hemant, He Weijing, Marconi Vincent C, Agan Brian K, Landrum Michael, Anderson Stephanie, Delmar Judith, Telles Vanessa, Song Li, Castiblanco John, Clark Robert A, Dolan Matthew J, Ahuja Sunil K
Abstract excerpt
A recent genome-wide association study (GWAS) suggested that polymorphisms in or around the genes HCP5, HLA-C and ZNRD1 confer restriction against HIV-1 viral replication or disease progression. Here, we also find that these alleles are associated with different aspects of HIV disease, albeit mainly in European Americans. Additionally, we offer that because the GWAS cohort was a subset of HIV-positive...
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