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Article

Global hypomethylation of genomic DNA in cancer-associated myofibroblasts.

Cancer research - 1 Dec 2008

Jiang Le, Gonda Tamas A, Gamble Mary V, Salas Martha, Seshan Venkatraman, Tu Shuiping, Twaddell William S, Hegyi Peter, Lazar Gyorgy, Steele Islay, Varro Andrea, Wang Timothy C, Tycko Benjamin

Abstract excerpt

Global hypomethylation has long been recognized as a feature of the malignant epithelial component in human carcinomas. Here we show evidence for this same type of epigenetic alteration in cancer-associated stromal myofibroblasts. We used methylation-sensitive SNP array analysis (MSNP) to profile DNA methylation in early-passage cultures of stromal myofibroblasts isolated from human gastric cancers. The MSNP data...

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Share to Chromosomal Instability
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to DNA, Neoplasm

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Share to Stomach Neoplasms

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Source

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Identifiers

PMID: 19047171
DOI: 10.1158/0008-5472.CAN-08-1319
PMCID: PMC2670548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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