Article
PTPN22 allele polymorphisms in 15 Chinese populations.
International journal of immunogenetics - 1 Dec 2008
Zhang Z-H, Chen F, Zhang X-L, Jin Y, Bai J, Fu S-B
Abstract excerpt
Protein tyrosine phosphatase non-receptor 22 (PTPN22) is involved in the negative regulation of T-cell responsiveness. Recently, it has been reported that a single nucleotide polymorphism (SNP), C1858T, in the gene PTPN22, encoding Arg620Trp in the lymphoid protein tyrosine phosphatase (LYP), is associated with an increased risk of a number of autoimmune diseases. To study the mutant frequency and polymorphism of...
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