Article
G protein Gs alpha (GNAS 1), the probable candidate gene for Albright hereditary osteodystrophy, is assigned to human chromosome 20q12-q13.2.
Genomics - 1 May 1991
Rao V V, Schnittger S, Hansmann I
Abstract excerpt
Guanine nucleotide-binding proteins, also known as G proteins, mediate intracellular responses to a wide variety of extracellular stimuli. A variety of genes that specify the synthesis of the components of guanine nucleotide proteins have been identified. One of these proteins, termed Gs alpha (GNAS1), is the G protein component of the olfactory signal transduction cascade. Mutations in the GNAS1 gene leading to...
Topics
- Chromosome Banding
- Chromosome Mapping
- Chromosomes, Human, Pair 20
- Fibrous Dysplasia, Polyostotic
- GTP-Binding Proteins
- Humans
- Male
- Mutation
- Pseudohypoparathyroidism
- Signal Transduction