GNAS mutations and heterotopic ossification.

Abstract excerpt

GNAS is a complex imprinted gene encoding the alpha-subunit of the stimulatory heterotrimeric G protein (Gsα). GNAS gives rise to additional gene products that exhibit exclusively maternal or paternal expression, such as XLαs, a large variant of Gsα that shows exclusively paternal expression and is partly identical to the latter. Gsα itself is expressed biallelically in most tissues, although the expression...

Topics

• Animals
• Chromogranins
• Cyclic AMP
• GTP-Binding Protein alpha Subunits, Gs
• Humans
• Mutation
• Ossification, Heterotopic