Article
The mouse hairy ears mutation exhibits an extended growth (anagen) phase in hair follicles and altered Hoxc gene expression in the ears.
Veterinary dermatology - 1 Dec 2008
Mentzer Sarah E, Sundberg John P, Awgulewitsch Alexander, Chao Hanna H J, Carpenter Donald A, Zhang Wei-Dong, Rinchik Eugene M, You Yun
Abstract excerpt
The mouse In(15)2Rl (hairy ears, Eh) mutation is a paracentric inversion of the distal half of chromosome 15 (Chr 15). Heterozygous Eh/+ mice display misshaped and hairy ears that have more and longer hair than the ears of their wild-type littermates. We mapped, cloned and sequenced both inversion breakpoints. No protein-coding transcript was disrupted by either breakpoint. The proximal breakpoint is located...
Topics
- Animals
- Chromosome Inversion
- Chromosome Mapping
- Cloning, Molecular
- Ear
- Female
- Gene Expression Regulation
- Genotype
- Hair
- Homeodomain Proteins
- Male