Article
Characterization of chromosomal inversion of the mouse hairy ears (Eh) mutation associated with cleft palate.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2007
Katayama Kentaro, Furuno Aki, Akiyama Kouyou, Tsuji Takehito, Kunieda Tetsuo
Abstract excerpt
The hairy ears (Eh) mutation in the mouse originated from neutron irradiation experiments and is associated with chromosomal inversion on chromosome 15. Eh/+ mice have small pinna and extra hairs on the pinna but the phenotypic features of Eh/Eh mice are unclear. In this study we found that Eh/Eh mice died shortly after birth and had a cleft palate caused by impaired growth of palate shelves. Because genes...
Topics
- Animals
- Animals, Newborn
- Apoptosis
- Base Pairing
- Cell Proliferation
- Chromosome Breakage
- Chromosome Deletion
- Chromosome Inversion
- Chromosomes, Mammalian
- Cleft Palate
- Crossing Over, Genetic
- Fetal Viability
- Gene Expression Regulation
- Genotype