Article
Comparison between weight-based and IGF-I-based growth hormone (GH) dosing in the treatment of children with GH deficiency and influence of exon 3 deleted GH receptor variant.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society - 1 Apr 2009
Marchisotti Frederico Guimarães, Jorge Alexander Augusto Lima, Montenegro Luciana Ribeiro, Berger Karina, de Carvalho Luciani Renata Silveira, Mendonca Berenice Bilharinho, Arnhold Ivo Jorge Prado
Abstract excerpt
OBJECTIVE: Compare the most frequently used weight-based GH dosing with an IGF-I level-based strategy in the treatment of children with severe GH deficiency. Additionally, analyse the influence of the GH receptor exon 3 polymorphism on IGF-I levels during GH therapy. DESIGN: Thirty children with GH deficiency on treatment with GH for 4.3+/-3.2 yr in a single University Hospital were divided in group W...
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