Article
Protein tyrosine phosphatase gene C1858T allele confers risk for rheumatoid arthritis in Hungarian subjects.
Rheumatology international - 1 May 2009
Farago Bernadett, Talian Gabor C, Komlosi Katalin, Nagy Gergely, Berki Timea, Gyetvai Agnes, Szekanecz Zoltan, Nyarady Zoltan, Kiss Csaba G, Nemeth Peter, Czirjak Laszlo, Melegh Bela
Abstract excerpt
The C1858T allele of the PTPN22 gene has been reported to confer risk for RA; but in some reports, the effect was restricted to RF- and/or anti-CCP-seropositive patients. Hungarian RA patients and matched controls were genotyped. The 1858T allele showed an increased prevalence in RA patients compared to controls. The 1858T allele represents a risk factor in the whole RA population (P = 0.001); an association was...
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