Article
Beta2-adrenergic receptor polymorphisms affect response to treatment in children with severe asthma exacerbations.
Chest - 1 May 2009
Carroll Christopher L, Stoltz Petronella, Schramm Craig M, Zucker Aaron R
Abstract excerpt
BACKGROUND: beta(2)-adrenergic receptor (AR) agonists are the mainstay of treatment for severe asthma exacerbations, one of the most common causes of critical illness in children. Genotypic differences in the beta(2)-AR gene, particularly at amino acid positions 16 and 27, have been shown to affect the response to beta(2)-AR agonist therapy. Our hypothesis is that genotypic differences contribute to patient...
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