Article
Effect of polymorphism of the beta(2)-adrenergic receptor on response to regular use of albuterol in asthma.
International archives of allergy and immunology - 1 Jan 2000
Israel E, Drazen J M, Liggett S B, Boushey H A, Cherniack R M, Chinchilli V M, Cooper D M, Fahy J V, Fish J E, Ford J G, Kraft M, Kunselman S, Lazarus S C, Lemanske R F, Martin R J, McLean D E, Peters S P, Silverman E K, Sorkness C A, Szefler S J, Weiss S T, Yandava C N
Abstract excerpt
BACKGROUND: Regular use of inhaled beta-adrenergic agonists may have adverse effects in some asthma patients. Polymorphisms of the beta(2)-adrenergic receptor (beta(2)-AR) can affect its regulation; however, results of smaller studies of the effects of such polymorphisms on response to beta-agonist therapy have been inconsistent. METHODS: We examined the possible effects of polymorphisms at codons 16...
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