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Article

Reduced adult endothelial cell EphB4 function promotes venous remodeling.

American journal of physiology. Cell physiology - 1 Apr 2013

Jadlowiec Caroline C, Feigel Amanda, Yang Chenzi, Feinstein Aaron J, Kim Susun T, Collins Michael J, Kondo Yuka, Muto Akihito, Dardik Alan

Abstract excerpt

Reduced EphB4 expression is observed during vein graft adaptation and is associated with increased venous wall thickening. These findings suggest that EphB4 may mediate normal adult venous endothelial cell (EC) function and vein graft adaptation. We therefore tested the functional significance of EphB4 using EC with genetically reduced EphB4 signaling. EC were isolated from EphB4(+/+) and EphB4(+/-) mice. In...

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Identifiers

PMID: 23269240
DOI: 10.1152/ajpcell.00333.2012
PMCID: PMC3625716

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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