Article
Critical role for GATA3 in mediating Tie2 expression and function in large vessel endothelial cells.
The Journal of biological chemistry - 16 Oct 2009
Song Haihua, Suehiro Jun-ichi, Kanki Yasuharu, Kawai Yoshiko, Inoue Kenji, Daida Hiroyuki, Yano Kiichiro, Ohhashi Toshio, Oettgen Peter, Aird William C, Kodama Tatsuhiko, Minami Takashi
Abstract excerpt
Endothelial phenotypes are highly regulated in space and time by both transcriptional and post-transcriptional mechanisms. There is increasing evidence that the GATA family of transcription factors function as signal transducers, coupling changes in the extracellular environment to changes in downstream target gene expression. Here we show that human primary endothelial cells derived from large blood vessels...
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